For healthy adults, the upper safe limit (UL) for vitamin C is set at 2000 mg/day (EFSA), so the 1000 mg per day in this product is well below that limit. Nevertheless, a note of caution applies: in a prospective cohort study, an additional (supplemental) dose of ≥1000 mg/day in men was associated with roughly double the relative risk of developing kidney (oxalate) stones compared to those without supplementation, whereas this association was not confirmed in women (Ferraro et al., 2016). If you have previously had kidney stones or belong to a risk group, consult a doctor before regular use.

Rosehip extract and citrus bioflavonoids are added to the formula because some data suggest that plant cofactors can improve cellular (leukocyte) uptake of vitamin C, although this does not necessarily affect plasma concentration (Calder, Kreider & McKay, 2025). In this product, the amount is relatively small (20 mg of rosehip), so its role is mainly supportive, while the main source of vitamin C remains the 1000 mg of L-ascorbic acid per tablet. On its own, rosehip extract is not essential for the basic effectiveness of vitamin C, but it can be a beneficial addition.

At a dosage of one tablet daily, a pack of 180 tablets will last approximately six months of use, which at a price of €21.99 works out to around €0.12 per tablet or per day – a competitive price for a 1000 mg dose compared to other products in the same category. Since this is a basic vitamin supplement without complex additional ingredients, the price per dose is a more important selection criterion than with more complex formulas.

Vitamin C does not prevent colds, and AdvancedU does not claim otherwise. A Cochrane systematic review found that regular daily supplementation with vitamin C (typically ≥200 mg/day in the included studies) did not significantly reduce the incidence of colds in the general population, but it was associated with an approximately 8% shorter duration and somewhat milder symptoms when taken regularly before symptoms appeared (Hemilä & Chalker, 2013). The 1000 mg dose per tablet in this product exceeds this studied range, but the result does not imply treatment or prevention of illness, only possible mild support during illness.